Tyr-MIF-1 attenuates antinociceptive responses induced by three models of stress-analgesia
نویسندگان
چکیده
منابع مشابه
Opioidergic system and second messengers affected the nociceptive effects of Tyr-MIF-1’s after three models of stress
The Tyr-MIF-1 family of neuropeptides (Tyr-MIF-1’s) includes MIF-1, Tyr-MIF-1, Tyr-W-MIF-1 and Tyr-K-MIF-1. Nowadays it is certain that they can modulate pain and some forms of stress-induced analgesia (SIA) by antiopiate and μ-specific processes. The objectives of the present study were twofold: 1) to determine the involvement of opioid system in analgesia induced by immobilization, cold and h...
متن کاملTyr-W-MIF-1 attenuates down-regulation of opiate receptors in SH-SY5Y human neuroblastoma cells.
Down-regulation of opiate receptors is demonstrated more easily in vitro than in vivo. The possible role of endogenous opiate-modulating peptides in preventing such down-regulation was investigated by addition of Tyr-W-MIF-1 to an in vitro preparation, the human neuroblastoma cell line SH-SY5Y, in which down-regulation of opiate receptors has been demonstrated previously. Although both morphine...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1987
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1987.tb11219.x